380 research outputs found
Bernstein-Szego Polynomials Associated with Root Systems
We introduce multivariate generalizations of the Bernstein-Szego polynomials,
which are associated to the root systems of the complex simple Lie algebras.
The multivariate polynomials in question generalize Macdonald's Hall-Littlewood
polynomials associated with root systems. For the root system of type A1
(corresponding to the Lie algebra SL (2;C)) the classic Bernstein-Szego
polynomials are recovered.Comment: LaTeX, 12 page
Multinet : enabler for next generation enterprise wireless services
Wireless communications are currently experiencing a fast migration toward the beyond third-generation (B3G)/fourth generation (4G) era. This represents a generational change in wireless systems: new capabilities related to mobility and new services support is required and new concepts as individual-centric, user-centric or ambient-aware communications are included. One of the main restrictions associated to wireless technology is mobility management, this feature was not considered in the design phase; for this reason, a complete solution is not already found, although different solutions are proposed and are being proposed. In MULTINET project, features as mobility and multihoming are applied to wireless network to provide the necessary network and application functionality enhancements for seamless data communication mobility considering end-user scenario and preferences. The aim of this paper is to show the benefits of these functionalities from the Service Providers and final User point of view
Heat stress develops with increased total-tract gut permeability, and dietary organic acid and pure botanical supplementation partly restores lactation performance in Holstein dairy cows
To evaluate the effects of heat stress (HS) conditions
and dietary organic acid and pure botanical (OA/PB)
supplementation on gut permeability and milk produc-
tion, we enrolled 46 multiparous Holstein cows [208 ±
4.65 dry matter intake (DMI; mean ± SD), 3.0 ± 0.42
lactation, 122 ± 4.92 d pregnant, and 39.2 ± 0.26 kg
of milk yield] in a study with a completely randomized
design. Cows were assigned to 1 of 4 groups: thermo-
neutral conditions (TN-Con, n = 12), HS conditions
(HS-Con, n = 12), thermoneutral conditions pair-fed
to HS-Con (TN-PF, n = 12), or HS supplemented with
OA/PB [75 mg/kg of body weight (BW); 25% citric
acid, 16.7% sorbic acid, 1.7% thymol, 1.0% vanillin,
and 55.6% triglyceride; HS-OAPB, n = 10]. Supple-
ments were delivered twice daily by top-dress; all cows
not supplemented with OA/PB received an equivalent
amount of the triglyceride used for microencapsulation
of the OA/PB supplement as a top-dress. Cows were
maintained in thermoneutrality [temperature-humidity
index (THI) = 68] during a 7-d acclimation and covari-
ate period. Thereafter, cows remained in thermoneutral
conditions or were moved to HS conditions (THI: diur-
nal change 74 to 82) for 14 d. Cows were milked twice
daily. Clinical assessments and BW were recorded,
blood was sampled, and gastrointestinal permeability
measurements were repeatedly evaluated. The mixed
model included fixed effects of treatment, time, and
their interaction. Rectal and skin temperatures and res-
piration rates were greater in HS-Con and HS-OAPB
relative to TN-Con. Dry matter intake, water intake,
and yields of energy-corrected milk (ECM), protein,
and lactose were lower in HS-Con relative to HS-OAPB.
Nitrogen efficiency was improved in HS-OAPB relative
to HS-Con. Compared with TN-Con and TN-PF, milk
yield and ECM were lower in HS-Con cows. Total-
tract gastrointestinal permeability measured at d 3 of
treatment was greater in HS-Con relative to TN-Con
or TN-PF. Plasma total fatty acid concentrations were
reduced, whereas insulin concentrations were increased
in HS-Con relative to TN-PF. We conclude that expo-
sure to a heat-stress environment increases total-tract
gastrointestinal permeability. This study highlights
important mechanisms that might account for milk
production losses caused by heat stress, independent
of changes in DMI. Our observations also suggest
that dietary supplementation of OA/PB is a means to
partly restore ECM production and improve nitrogen efficiency in dairy cattle experiencing heat stress
Relational Goods and Endurance of Voluntary Associational Participation: The Mapuche Indigenous Case in Santiago de Chile.
In this article, I analyse the reasons for sustaining membership in voluntary
ethnic associations of Mapuche people living in Santiago de Chile. By following a relational goods approach, I suggest that the constructed nature of ethnicity leads the Mapuche to create and join ethnic associations in an urban milieu. This study reveals that the main motivations for sustaining an active associational engagement in Santiago are based on three accounts: identity recovery struggle, leaving an identity legacy and bonding with their ethnic peers; all of these identified as relational goods. This investigation is based on an eight-month ethnographic fieldwork conducted in Santiago.This work was supported by the University of Cambridge Sociology Graduate Education Committee (GEC) Fieldwork Funding; Newnham College, University of Cambridge Fieldwork Grant; and under the Programme Becas de Doctorado con Acuerdo Bilateral en el Extranjero Becas Chile-Cambridge (Grant Fondecyt: N° 84140015)
Immune Biomarkers in Metastatic Castration-resistant Prostate Cancer.
BACKGROUND: Metastatic castration-resistant prostate cancer (mCRPC) is a heterogeneous disease in which molecular stratification is needed to improve clinical outcomes. The identification of predictive biomarkers can have a major impact on the care of these patients, but the availability of metastatic tissue samples for research in this setting is limited. OBJECTIVE: To study the prevalence of immune biomarkers of potential clinical utility to immunotherapy in mCRPC and to determine their association with overall survival (OS). DESIGN, SETTING, AND PARTICIPANTS: From 100 patients, mCRPC biopsies were assayed by whole exome sequencing, targeted next-generation sequencing, RNA sequencing, tumor mutational burden, T-cell-inflamed gene expression profile (TcellinfGEP) score (Nanostring), and immunohistochemistry for programmed cell death 1 ligand 1 (PD-L1), ataxia-telangiectasia mutated (ATM), phosphatase and tensin homolog (PTEN), SRY homology box 2 (SOX2), and the presence of neuroendocrine features. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: The phi coefficient determined correlations between biomarkers of interest. OS was assessed using Kaplan-Meier curves and adjusted hazard ratios (aHRs) from Cox regression. RESULTS AND LIMITATIONS: PD-L1 and SOX2 protein expression was detected by immunohistochemistry (combined positive score â„1 and >5% cells, respectively) in 24 (33%) and 27 (27%) mCRPC biopsies, respectively; 23 (26%) mCRPC biopsies had high TcellinfGEP scores (>-0.318). PD-L1 protein expression and TcellinfGEP scores were positively correlated (phi 0.63 [0.45; 0.76]). PD-L1 protein expression (aHR: 1.90 [1.05; 3.45]), high TcellinfGEP score (aHR: 1.86 [1.04; 3.31]), and SOX2 expression (aHR: 2.09 [1.20; 3.64]) were associated with worse OS. CONCLUSIONS: PD-L1, TcellinfGEP score, and SOX2 are prognostic of outcome from the mCRPC setting. If validated, predictive biomarker studies incorporating survival endpoints need to take these findings into consideration. PATIENT SUMMARY: This study presents an analysis of immune biomarkers in biopsies from patients with metastatic prostate cancer. We describe tumor alterations that predict prognosis that can impact future studies
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